Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease
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چکیده
منابع مشابه
Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease.
It is well established that Alzheimer's disease causing mutations in APP, PSEN1 and PSEN2 lead to a relative increased production of Abeta42, thereby fostering its deposition in plaques. Recently others and we showed that amyloid precursor protein (APP) overproduction, either as a result of genomic locus duplication or altered regulatory sequences in the APP promoter region, leads to early-onse...
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how to cite this article: bhadbhade a, cheng dw. amyloid precursor protein processing in alzheimer’s disease. iranian journal of child neurology2012;6(1):1-5. alzheimer’s disease (ad) is a progressive neurodegenerative disorder and a leading cause of dementia. the ad is characterized by presence of intraneuronal tangles and extracellular plaques in the brain. the plaques are composed of dense a...
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Objective(s): Increasing evidence suggests that Alzheimer’s disease (AD) is associated with diabetes. Rosiglitazone, a peroxisome proliferator-activated receptor γ (PPAR-γ) agonist and anti-diabetic agent, may improve symptoms of AD. However, the underlying therapeutic potential of it has not been fully elucidated. Materials and Methods: Rats were divided into four groups: control group, sham o...
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Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated and cleaved forms of the microtubule-associated protein tau. Genetic, biochemical, and behavioral research suggest that physiologic generation of the neurotoxic Aβ peptide from sequential amyloid precursor protein (...
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Introduction: Iron oxide nanoparticles (Fe2O3-NPs) are small magnetic particles that widely used in different aspects of biology and medicine in modern life. Fe2O3-NP accumulated in the living cells due to absence of active system to excrete the iron ions so damages cellular organelles by highly reactivity. Method: Herein cytotoxic effects of Fe2O3-NP with 50 nm size were investigated on prima...
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ژورنال
عنوان ژورنال: Brain
سال: 2006
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awl212